This session provides a clinical and industry perspective on how informatics and AI is shaping, redefining and disrupting our tomorrow.  Our healthcare environment today is having to cope with multiple demands and challenges. The complexity of the workload – clinical and non-clinical – have increased. The expectations of patients and professionals have risen, exceeding existing or future capability and capacity.   Concurrently, there are advances in Medical & Imaging Informatics and AI, seemingly promising to revolutionise the way we work and manage patients. To fully capitalise on Medical and Radiology AI, there is a strong need for a robust and stable Medical and Imaging informatics environment.  With massively increasing data volumes, new medical innovation developments including AI, and associated hype/hope: there are unique demands posed on your fast evolving imaging ecosystem.  Whilst industry can provide solutions, there is a need to collaborate closely with Healthcare Professionals and Leadership to locate the pain points, the inefficiencies and inadequacies present in the healthcare environment.   There needs to be close collaboration and coordination between i. real challenges clinical teams and diagnostic sciences teams encounter and ii. industries & R&D teams responses. Adaptability of solutions to fit clinical practice and workflow is discussed and One-size-fits-all solution may not be the best future proof option.   The session has a special focus on value of clinical insights gained from medical informatics and AI as part of end-to-end clinical imaging workflow, and how this is helping healthcare professionals accelerate productivity and increase patient benefits.